Our laboratory uses a combination of electrophysiological and imaging techniques to study the modulation of neuronal activity ("neuromodulation") in the mammalian central nervous system. Current research directions include:

  • RGS modulation of the antiepileptic properties of alpha2a-AR activation by NE
  • The role of alpha1a-AR activation in adult neurogenesis
  • The effects of Cadmium on adult neurogenesis

A list of representative publications is shown below. Also, please visit the websites of our collaborators and close associates.

  • alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse.
    Doze VA, Handel EM, Jensen KA, Darsie B, Luger EJ, Haselton JR, Talbot JN, Rorabaugh BR.
    Brain Res. 2009 Aug 18;1285:148-57. Epub 2009 Jun 18.
    PMID: 19540213 [PubMed - in process]
  • alpha1-Adrenergic receptors regulate neurogenesis and gliogenesis.
    Gupta MK, Papay RS, Jurgens CW, Gaivin RJ, Shi T, Doze VA, Perez DM.
    Mol Pharmacol. 2009 Aug;76(2):314-26. Epub 2009 Jun 1.
    PMID: 19487244 [PubMed - indexed for MEDLINE]
  • Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity.
    Goldenstein BL, Nelson BW, Xu K, Luger EJ, Pribula JA, Wald JM, O'Shea LA, Weinshenker D, Charbeneau RA, Huang X, Neubig RR, Doze VA.
    Mol Pharmacol. 2009 May;75(5):1222-30. Epub 2009 Feb 18.
    PMID: 19225179 [PubMed - indexed for MEDLINE]
  • Alpha-1A adrenergic receptor activation increases inhibitory tone in CA1 hippocampus.
    Hillman KL, Lei S, Doze VA, Porter JE.
    Epilepsy Res. 2009 Apr;84(2-3):97-109. Epub 2009 Feb 6.
    PMID: 19201164 [PubMed - indexed for MEDLINE]
  • Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus.
    Hillman KL, Doze VA, Porter JE.
    J Pharmacol Exp Ther. 2007 Jun;321(3):1062-8. Epub 2007 Mar 2.
    PMID: 17337632 [PubMed - indexed for MEDLINE]
  • Alpha2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region.
    Jurgens CW, Hammad HM, Lichter JA, Boese SJ, Nelson BW, Goldenstein BL, Davis KL, Xu K, Hillman KL, Porter JE, Doze VA.
    Mol Pharmacol. 2007 Jun;71(6):1572-81. Epub 2007 Mar 6.
    PMID: 17341653 [PubMed - indexed for MEDLINE]

For a full listing of publications, please visit PubMed (author "Doze VA").